The term "up setters" can be used to describe people or things that cause disruption or upset. Some common synonyms for this term might include agitators, instigators, provocateurs, or troublemakers. Other possible alternatives might include disruptors, rabble-rousers, or inciters. Depending on the context, other words might also be suitable to describe people or things that cause disturbance or upset, such as dissenters, rebels, or contrarians. Ultimately, the choice of synonym may depend on the tone and intended meaning of the message, as well as the specific circumstances being discussed.