Expressing despair or distress is a common human emotion that can be demonstrated in various ways. Instead of using the phrase "demonstrate anguish against," there are many synonyms that can be used to convey this emotion more effectively. Some alternative phrases are "show agony towards," "express torment over," "display misery about," or "reveal pain concerning." Other suggestions could be "exhibit grief against," "portray sorrow towards," or "manifest lament over." Whatever words or phrases you choose to use, it's important to pick those that accurately reflect the level of emotion you intend to convey and are appropriate for the context in which they are being used.